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Human corticosteroid binding globulin

T G Brien

    Clinical Endocrinology
    |February 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Corticosteroid binding globulin (CBG), also known as transcortin, is crucial for regulating cortisol levels. This review covers its properties, production, measurement, and variations, especially during pregnancy and oral contraceptive use.

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    Area of Science:

    • Endocrinology
    • Biochemistry
    • Human Physiology

    Background:

    • Corticosteroid binding globulin (CBG), also known as transcortin, is the primary high-affinity plasma transport protein for cortisol.
    • Understanding CBG is essential for interpreting cortisol levels and its physiological effects.

    Purpose of the Study:

    • To provide a comprehensive review of the current literature on corticosteroid binding globulin (transcortin).
    • To detail its physicochemical properties, biosynthesis, measurement techniques, and variations.
    • To emphasize the impact of pregnancy and oral contraceptives on CBG levels and function.

    Main Methods:

    • Literature review of scientific articles and studies on corticosteroid binding globulin.
    • Synthesis of information regarding CBG's properties, production, and clinical relevance.

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  • Analysis of data related to physiological, pharmacological, and pathological variations.

    • Main Results:

    • CBG exhibits specific physicochemical properties influencing steroid hormone transport.
    • Its biosynthesis and measurement methods have been refined over time.
    • Significant variations in CBG levels and function are observed during pregnancy and with oral contraceptive use, impacting cortisol bioavailability.

    Conclusions:

    • Corticosteroid binding globulin plays a vital role in regulating the bioavailability and physiological actions of glucocorticoids.
    • Further research into CBG's implications is warranted for a complete understanding of endocrine function and disease states.