Trazodone in depression

Dose comparison trials were undertaken with trazodone given once, twice and thrice daily. Therapeutic effects were the same but once daily dosage produced drowsiness whilst thrice daily dosage did not. In a double-blind comparison to imipramine, anti-depressant effects were similar, except at 6 weeks when imipramine was significantly better. There were no significant differences in relief of anxiety symptoms.