Evidence that the arginine esteropeptidase (gamma) subunit of nerve growth factor can activate inactive renin

The beta and gamma subunits of nerve growth factor were isolated and tested for inactive-renin-activating activity using human amniotic fluid as a convenient source of inactive renin. Only the gamma subunit, which is an arginine esteropeptidase, could activate inactive renin. The role of this enzyme in sites containing both it and inactive renin warrants investigation.