Relationship between asthma and gastro-oesophageal reflux

Area of Science:

• Gastroenterology
• Pulmonology
• Clinical Pharmacology

Background:

• Gastro-oesophageal reflux is a common condition.
• Bronchial asthma affects millions worldwide.
• A potential link between gastro-oesophageal reflux and asthma exacerbations has been suggested.

Purpose of the Study:

• To investigate the impact of treating gastro-oesophageal reflux on respiratory symptoms in asthma patients.
• To assess the efficacy of cimetidine in managing asthma symptoms associated with reflux.

Main Methods:

• Twenty patients with bronchial asthma and gastro-oesophageal reflux were enrolled.
• Reflux severity was assessed using symptom scores and diagnostic tests (barium swallow, endoscopy, manometry, pH monitoring, acid infusion).
• A double-blind crossover study using cimetidine was conducted, with lung function tests and home peak flow monitoring.

Main Results:

• Eighteen patients completed the study.
• Significant improvements were observed in reflux symptoms and nighttime asthma symptoms.
• A statistically significant improvement in the last daily peak flow reading was noted.
• Fourteen patients reported substantial improvement in their chest symptoms during cimetidine treatment.

Conclusions:

• Cimetidine treatment for gastro-oesophageal reflux led to notable improvements in asthma symptoms and lung function.
• These findings support the hypothesis that gastro-oesophageal reflux can negatively impact asthma control.
• Targeting reflux may be a beneficial strategy for managing certain asthma patients.