Progestin permeation through polymer membranes I: diffusion studies on plasma-soaked membranes

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Controlled-release drug delivery systems require biocompatible polymers with predictable drug permeation.
• Hydrophobic drugs present unique challenges for diffusion through polymeric membranes.

Purpose of the Study:

• To evaluate commercially available polymers for controlled-release drug delivery.
• To assess the impact of plasma exposure on drug permeation through these polymers.

Main Methods:

• Progesterone permeation rates were measured through various polymers: polydimethylsiloxane, polyether urethanes, hydroxyethyl methacrylate, a blend, and a cellulosic membrane.
• Membranes were tested in both non-soaked and plasma-soaked states to simulate physiological conditions.

Main Results:

• Several polymers demonstrated potential for progesterone-controlled release.
• Plasma soaks indicated that lipid absorption and degradation affected polymer permeability, with some materials becoming unsuitable.

Conclusions:

• Polydimethylsiloxane, polyether urethanes, and cellulosic membranes show potential for drug delivery applications.
• Plasma exposure is a critical factor in assessing polymer suitability for in vivo controlled-release systems.