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Creutzfeld-Jakob disease

A Tarkkanen, M Haltia

    Transactions of the Ophthalmological Societies of the United Kingdom
    |April 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Autopsy examination of Creutzfeldt-Jakob disease (CJD) patients

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    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Neuropathology

    Background:

    • Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative prion disease.
    • Ocular manifestations in CJD are not well-documented, prompting investigation into ocular pathology.

    Observation:

    • Autopsy eyes from two CJD patients were examined histopathologically.
    • Clinical examination in one patient showed no specific ocular findings prior to death.

    Findings:

    • No infectious agents or structural damage were found in the cornea or retina.
    • The optic nerve head, including axons and glial cells, was intact.
    • Increased astrocyte cellularity was observed in the optic nerves anterior and posterior to the lamina cribrosa.

    Implications:

    • The study identifies specific neuropathological changes in the optic nerve associated with CJD.
    • These findings may contribute to understanding the broader impact of CJD on the visual pathway.
    • Further research could explore the functional significance of optic nerve astrogliosis in CJD.