Improved synthesis of N-(2,6-dimethylphenylcarbamoylmethyl) iminodiacetic acid and analogs

A new synthesis of N-(2,6-dimethylphenylcarbamoyl-methyl)iminodiacetic acid directly from nitrilotriacetic acid was developed. Six analogs also were synthesized. Their technetium Tc 99m complexes were prepared and characterized. Electrophoresis and chromatography were used to determine the radiochemical purity of each complex.