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Dissolution profiles of drugs from tablets

N Kitamori, K Iga

    Journal of Pharmaceutical Sciences
    |October 1, 1978
    PubMed
    Summary

    A new theoretical equation models drug dissolution from tablets by integrating tablet disintegration and particle dissolution rates. This model reveals that rapid particle dissolution makes tablet disintegration the primary factor influencing drug release profiles.

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    Area of Science:

    • Pharmaceutical Sciences
    • Physical Chemistry

    Background:

    • Tablet disintegration and particle dissolution are critical factors influencing drug release kinetics.
    • Existing models often simplify or neglect the interplay between these two processes.

    Purpose of the Study:

    • To develop a comprehensive theoretical equation for drug dissolution from tablets.
    • To investigate the combined influence of tablet disintegration and particle dissolution on drug release profiles.

    Main Methods:

    • Derived a theoretical equation by combining tablet disintegration and particle dissolution equations.
    • Incorporated assumptions regarding particle release kinetics and spherical particle dissolution.
    • Utilized computer simulations to generate tablet dissolution versus time plots.

    Main Results:

    • The derived equation produced an S-shaped dissolution curve, bridging dissolution from immediate particle release and delayed release.
    • Examined the joint effects of disintegration and particle dissolution on the overall tablet dissolution profile.
    • Demonstrated that tablet disintegration predominantly influences dissolution when particle dissolution is rapid.

    Conclusions:

    • The developed theoretical framework accurately describes drug dissolution from tablets, considering both disintegration and particle dissolution.
    • The relative importance of disintegration and particle dissolution is dependent on the intrinsic dissolution rate of the drug particles.
    • This model provides a valuable tool for predicting and optimizing drug release from solid dosage forms.

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