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Quinazolinylformamidines and quinazolinediylbisformamidines as antihypertensive agents

J D Warren, S A Lang, P S Chan

Journal of Pharmaceutical Sciences

|October 1, 1978

Abstract:

Eleven quinazolinylformamidines and quinazolinediylbisformamidines were synthesized and investigated for antihypertensive activity in spontaneous hypertensive rats. Several compounds showed moderate antihypertensive activity at 100 mg/kg po. The same compounds were not hypotensive in the normotensive dog.

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