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Protein folding

M G Rossmann, P Argos

    Annual Review of Biochemistry
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This review details protein structural organization, from primary to tertiary levels, emphasizing functional domains and taxonomic classification. It explores protein folding, disulfide bonds, and evolutionary patterns like convergence and divergence.

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    Area of Science:

    • Biochemistry
    • Structural Biology
    • Bioinformatics

    Background:

    • Proteins are fundamental biological macromolecules with complex three-dimensional structures.
    • Understanding protein structure is crucial for deciphering biological function and disease mechanisms.

    Purpose of the Study:

    • To provide a comprehensive overview of protein structural organization.
    • To examine the hierarchical levels of protein structure: primary, secondary, and tertiary.
    • To discuss the role of functional domains and their classification.

    Main Methods:

    • Review of existing literature on protein structure and classification.
    • Analysis of protein folding principles, including disulfide bond conformation.
    • Exploration of secondary structures (helices, sheets, turns) and super-secondary structures.

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  • Examination of tertiary structure, focusing on domains as functional units.
  • Discussion of domain recognition, protein taxonomy, and evolutionary aspects.

    • Main Results:

    • Detailed description of primary, secondary, and tertiary protein organization.
    • Emphasis on domains as key functional units within polypeptide chains.
    • Introduction of a taxonomic protein classification based on structure and function.
    • Exploration of the impact of metals and prosthetic groups on protein folding.
    • Consideration of evolutionary convergence and divergence in protein structures.

    Conclusions:

    • Protein structure is intricately linked to function, with domains playing a critical role.
    • A structure- and function-based classification system aids in understanding protein diversity.
    • Evolutionary processes significantly shape protein architecture and function.