Genetic regulation and development of alcohol dehydrogenases in the mouse

Alcohol dehydrogenase (ADH) of mouse tissues was investigated using electrophoretic zymogram methods. ADH activity is widely distributed in mouse tissues and exists as at least two genetic isozymes, designated A2 and C2, which are predominantly localised in liver and stomach respectively. Electrophoretic and activity variants of ADH-C2 among inbred strains of mice have been used to localise the gene encoding this enzyme (Adh-3) and a closely linked temporal locus (Adh-3-t) on chromosome 3 of this organism. Recent developmental studies on ADH isozymes in the mouse have been reviewed.