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Trimethoprim: clinical use and pharmacokinetics
Drug Intelligence & Clinical Pharmacy
|May 1, 1981
Summary
Trimethoprim (TMP) is a single-drug antibiotic of interest for common infections. This review covers its history, antibacterial properties, clinical uses, adverse effects, and renal handling advantages over TMP/sulfonamide combinations.
Area of Science:
- Pharmacology
- Infectious Diseases
- Antimicrobial Agents
Background:
- Trimethoprim (TMP) is now marketed as a single agent, increasing interest in its therapeutic applications.
- Understanding the history and antibacterial spectrum of TMP is crucial for its effective clinical use.
Purpose of the Study:
- To review the history, antibacterial properties, and clinical indications of trimethoprim.
- To explore potential new uses for trimethoprim.
- To discuss the significance of adverse effects and compare TMP's pharmacokinetics with TMP/sulfonamide combinations, focusing on renal handling.
Main Methods:
- Literature review of trimethoprim's history, pharmacology, and clinical applications.
- Analysis of pharmacokinetic data, particularly renal excretion and toxicity profiles.
- Comparison of single-drug TMP with TMP/sulfonamide combinations regarding renal function.
Main Results:
- Trimethoprim exhibits broad-spectrum antibacterial activity.
- Established clinical indications and potential novel uses for TMP are presented.
- Pharmacokinetic review highlights TMP's favorable renal handling and potential advantages over combination therapies in certain patient groups.
Conclusions:
- Trimethoprim offers a valuable therapeutic option for common infections.
- Its distinct pharmacokinetic profile, especially concerning renal function, presents advantages over traditional TMP/sulfonamide combinations.
- Further exploration of TMP's applications and safety is warranted.