Synthetic insulin by selective disulfide briding, II. Polymer phase synthesis of the human B chain fragments

Five protected fragments Ddz-Phe-Val-Asn(Mbh)-Gln(Mbh)-His(Dnp)-Leu-Cys(Acm)-Gly-OH [I], Ddz-Ser(But)-His(Dnp)-Leu-Val-Glu-(OBut)-Ala-OH [II], Ddz-Leu-Tyr(But)-Leu-Val-Cys(Mbzl)-Gly-OH [III], Ddz-Glu(OBut)-Arg(Tos)-Gly-OH [IV], Ddz-Phe-Phe-Tyr(But)-thr(But)-Pro-Lys(Z)-Thr(But)-OH [V] for the synthesis of the human insulin B chain, were prepared by an efficient procedure on solid phase.