[Persistent acantholytic dermatosis]

A 43 years old male patient with a pruritic, papular and papulovesicular eruption of 8 years duration is reported. The lesions come in crops (4-5 a year) of variable duration (4 days a 2 months) and are not influenced by treatment except, perhaps, systemic corticotherapy. Histologically there is focal acantholysis of limited extension but often involving the whole thickness of the stratum malpighi. The relationships between the persistent and the transient varieties of Greover's disease are discussed as well as the ones with cutaneous diseases in which focal acantholytic dyskeratosis has been observed.