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The placenta: a diagnostic tool in sickle cell disorders
Journal of the National Medical Association
|February 1, 1978
Summary
Placental examination accurately detects sickle cell disorders. This simple, inexpensive method confirmed 24 cases and identified two false negatives from standard tests.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Pathology
Background:
- Sickle cell disorders are inherited blood conditions.
- Accurate diagnostic methods are crucial for patient management.
- Conventional testing may yield false negative results.
Purpose of the Study:
- To evaluate placental examination as a diagnostic tool for sickle cell disorders.
- To assess the accuracy and feasibility of this method.
Main Methods:
- Examination of placental specimens for evidence of sickling.
- Comparison of results with conventional diagnostic testing.
Main Results:
- Sickling was detected in 24 out of 904 placental specimens.
- The technique proved accurate and readily available.
- Two cases of false negative results from conventional testing were identified.
Conclusions:
- Placental examination is a reliable, cost-effective method for diagnosing sickle cell disorders.
- This technique can serve as a valuable confirmatory procedure, improving diagnostic accuracy.