Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Erythrocyte shape transformation associated with calcium accumulation

J M Kretchman, B S Rogers

    The American Journal of Medical Technology
    |July 1, 1981
    PubMed
    Summary

    High calcium levels in red blood cells cause shape changes, reducing their flexibility and lifespan. This review explores how calcium impacts erythrocyte morphology by affecting internal cytoskeletal proteins.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A course in electronics and instrumentation.

    The American journal of medical technology·1981
    Same author

    Case study: Drug-induced hemolytic anemia.

    The American journal of medical technology·1981
    Same author

    Voice of the ward sister.

    Nursing focus·1981
    Same author

    Middle East health services.

    Nursing focus·1981
    Same author

    TO REFILL OR NOT TO REFILL.

    The Journal of the Florida Medical Association. Florida Medical Association·1963
    Same author

    Toxicity, metabolism, and tissue distribution of carbon-14 labeled N,N',N"-triethylenethiophosphoramide (Thio-TEPA) in rats.

    Toxicology and applied pharmacology·1962

    Area of Science:

    • Hematology
    • Cell Biology
    • Biochemistry

    Background:

    • Calcium influx into erythrocytes alters cell shape and deformability.
    • Altered erythrocyte morphology, specifically disco-spheroechinocyte transformation, shortens cell lifespan.
    • The precise mechanisms linking calcium to these morphologic changes require further elucidation.

    Purpose of the Study:

    • To review the role of calcium in erythrocyte morphologic alterations.
    • To discuss the involvement of inner membrane cytoskeletal proteins in calcium-induced shape changes.
    • To hypothesize the molecular interactions between calcium and cytoskeletal proteins leading to echinocytosis.

    Main Methods:

    • Literature review of studies on calcium, erythrocytes, and cell morphology.
    • Analysis of proposed mechanisms involving cytoskeletal protein modification.
    • Examination of experimental evidence supporting calcium-erythrocyte interactions.

    Main Results:

    • Calcium accumulation induces a disco-spheroechinocyte transformation in erythrocytes.
    • This transformation is associated with a significant loss of cellular deformability.
    • The process appears to involve modifications to the erythrocyte's inner membrane cytoskeletal proteins.

    Conclusions:

    • Calcium plays a critical role in the shape transformation and reduced deformability of erythrocytes.
    • Modifications to cytoskeletal proteins are central to calcium-induced erythrocyte shape changes.
    • Calcium-mediated alterations in cytoskeletal protein state or arrangement likely cause the echinocytic shape through a contractile response.

    Related Experiment Videos