Related Experiment Video
Updated: Aug 15, 2026

Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
Osteogenesis imperfecta: historical background
Abstract:
Approximately 100 years of observation and investigation have demontrated that the terms osteopsathyrosis idiopathica and OI refer to the same disease process. Classically, three cardinal symptoms have been described: bone fragility, blue sclerae and deafness. It is now known that this combination of findings is most likely to appear in patients with the milder form of the disease, and even in this group only some of the patients have all three symptoms. Historically, a hereditary mesenchymal defect transmitted by autosomal dominance has been implicated in the etiology.
Related Concept Videos
Bone Remodeling
Osteoclasts in Bone Remodeling
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Formation by Endochondral Ossification

