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Ionized calcium in body fluids

W G Robertson, R W Marshall

    Critical Reviews in Clinical Laboratory Sciences
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    This review covers methods for measuring ionized calcium in body fluids like blood and urine. It highlights techniques such as bioluminescence, colorimetry, and ion-selective electrodes, assessing their accuracy and clinical importance.

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    Area of Science:

    • Clinical Chemistry
    • Analytical Biochemistry
    • Biomedical Measurement

    Background:

    • Ionized calcium plays a critical role in numerous physiological processes.
    • Accurate measurement of ionized calcium is essential for clinical diagnosis and management.
    • Existing methods for total calcium measurement may not reflect the physiologically active fraction.

    Purpose of the Study:

    • To review current methods for measuring ionized calcium concentration in diverse body fluids.
    • To evaluate the precision, accuracy, and potential errors of these measurement techniques.
    • To assess the clinical significance of ionized calcium versus total calcium determination.

    Main Methods:

    • Review of analytical techniques including bioluminescence, colorimetry, and ion-selective electrodes.

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  • Analysis of measurement procedures for whole blood, serum, plasma, urine, cerebrospinal fluid, milk, and synovial fluid.
  • Identification of potential sources of error and interfering substances for each method.

    • Main Results:

    • Detailed comparison of the performance characteristics (precision, accuracy) of different ionized calcium measurement methods.
    • Guidelines for optimal measurement conditions in various biological matrices.
    • Identification of specific challenges and limitations associated with each technique.

    Conclusions:

    • Ionized calcium measurement offers critical clinical insights beyond total calcium analysis.
    • Selection of appropriate methodology is crucial for reliable ionized calcium determination.
    • Continued refinement of measurement techniques will enhance diagnostic capabilities in clinical medicine.