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Immunosuppressive effects of tween 80 on mice
International Archives of Allergy and Applied Immunology
|January 1, 1981
Summary
Tween 80 significantly suppressed the primary IgM humoral immune response in mice, as shown by the Jerne plaque assay. However, it did not affect the secondary IgG response or cell-mediated immunity.
Area of Science:
- Immunology
- Pharmacology
Background:
- The non-ionic surfactant Tween 80 is widely used in pharmaceutical formulations.
- Understanding its potential immunomodulatory effects is crucial for drug safety.
Purpose of the Study:
- To investigate the impact of Tween 80 on both humoral and cell-mediated immune responses in mice.
Main Methods:
- Humoral immunity was assessed using the Jerne plaque assay to quantify primary (IgM) and secondary (IgG) antibody-producing cells.
- Cell-mediated immunity was evaluated by measuring contact hypersensitivity to oxazolone.
Main Results:
- Tween 80 treatment led to a significant reduction in primary IgM plaque-forming cells.
- No significant changes were observed in the number of secondary IgG plaques.
- Contact hypersensitivity responses remained unaffected by Tween 80 administration.
Conclusions:
- Tween 80 selectively suppresses the primary humoral immune response, specifically IgM production.
- It does not appear to impact secondary humoral immunity or cell-mediated immune functions.
