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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Measles virus and chronic infections

T F Wild

    Pathologie-Biologie
    |September 1, 1981
    PubMed

    Insights

    Measles virus can cause immediate complications or lead to long-term neurological diseases like subacute sclerosing panencephalitis. This review examines models of measles virus persistence and its links to other chronic conditions.

    Area of Science:

    • Virology
    • Neurology
    • Immunology

    Background:

    • Measles virus infection typically presents as a common childhood illness.
    • Complications can include acute encephalitis and pneumonia.
    • Long-term sequelae, such as subacute sclerosing panencephalitis (SSPE), can emerge years after initial infection.

    Purpose of the Study:

    • To review the role of measles virus in persistent infections.
    • To compare in vitro and in vivo models of measles virus persistence.
    • To discuss the association of measles virus with other chronic diseases.

    Main Methods:

    • Literature review of studies on measles virus persistence.
    • Comparison of experimental models (in vitro and in vivo) with human disease parameters.
    • Analysis of evidence linking measles virus to long-term conditions.

    Main Results:

    • Measles virus can establish persistent infections.
    • Various models exist to study measles virus persistence.
    • Evidence suggests a potential association between measles virus and diseases like multiple sclerosis and Paget's bone disease.

    Conclusions:

    • Measles virus is implicated in both acute and chronic disease manifestations.
    • Understanding measles virus persistence is crucial for managing long-term health impacts.
    • Further research is needed to elucidate the mechanisms linking measles virus to other chronic diseases.

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