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Flurbiprofen and intraocular pressure

D K Gieser, E Hodapp, I Goldberg

    Annals of Ophthalmology
    |July 1, 1981
    PubMed
    Summary
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    Corticosteroids can increase intraocular pressure (IOP). This study found that flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), did not affect IOP or block corticosteroid-induced ocular hypertension.

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Corticosteroids, when administered systemically or topically, can elevate intraocular pressure (IOP).
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) represent an alternative therapeutic option for managing ocular inflammatory conditions.

    Purpose of the Study:

    • To investigate the effect of flurbiprofen, a novel NSAID, on intraocular pressure (IOP).
    • To determine if flurbiprofen influences IOP in individuals who are known high responders to corticosteroids.

    Main Methods:

    • A double-masked study design was employed to assess the impact of flurbiprofen on IOP.
    • The study evaluated flurbiprofen's effect in patients with a history of elevated IOP in response to corticosteroids.

    Main Results:

    Related Experiment Videos

  • Flurbiprofen administration did not result in any significant alteration of intraocular pressure (IOP).
  • Flurbiprofen did not inhibit or prevent the rise in IOP typically induced by corticosteroid treatment.

    • Conclusions:

    • Flurbiprofen appears to be safe concerning intraocular pressure (IOP) modulation.
    • Flurbiprofen does not interfere with the hypertensive effects of corticosteroids on the eye.