DNA distribution in various parts of malignant gliomas assayed on stereotactic biopsies

The study concerns the relation between the computerized tomogram, histopathology and DNA distribution in gliomas. The investigation was performed on stereotactic biopsies, which enabled the comparison to be made on a point-to-point basis. No clear-cut relation was found between histopathological grading and DNA distribution. In 1 patient diploid and aneuploid tissue was found in different parts of the tumor. In this case the difference in ploidy was mirrored by differences in histopathological grading and gross morphology as indicated by the CT scan.