Exercise-induced proteinuria in children and adolescents with type 1 (insulin dependent) diabetes

The urinary excretion excretion of albumin and Beta2-microglobulin was measured by radioimmunoassay in 64 children and adolescents with Type 1 (insulin dependent) diabetes and in 68 non-diabetic subjects aged from 9 to 19 years. At rest the albumin excretion of te diabetic subjects did not differ from that of te non-diabetic children and adolescents but during exercise the albumin excretion was significantly higher in children and adolescents with Type 1 diabetes (p less than 0.02). the excretion rate of Beta2-microglobulin in diabetic subjects did not differ from that of the healthy subjects. Both at rest and during exercise the albumin excretion rate was highest in those diabetics with poorest metabolic control of their disease.