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Updated: Aug 14, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
The effect of marrow on the formation of "functionally" oriented collagen fibers
Abstract:
It has been shown that "functionally" oriented collagen fibers will attach to cementum when a healthy root fragment is implanted subcutaneously along with decalcified autogenous bone. The purpose of the present study was to test the effect of a strong bone grower (marrow) on this inductive system. Twenty-six composite grafts of healthy root, decalcified autogenous bone and marrow were implanted in thirteen 200 gm, female, white, Sherman-strain rats. Sixteen composite grafts without roots were similarly implanted, as controls, into eight animals. Postoperative periods ranged from 1 week to 8 months. With the exception of one section, the results showed that the addition of marrow prevented the formation of "functionally" oriented fibers. It is further evidence that strong bone formers do not produce a periodontium.
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