[A study in dogs of micropellets for use in angiographic therapeutic procedures (author's transl)]

A study was conducted in dogs to evaluate the effect on the organism of a new embolisation material: carnauba wax micropellets. The ultimate objective was to study the possible use of micropellets containing an active product for therapy in situ. Renal embolisation was performed by selective or highly selective arterial catheterisation in dogs. Pathological examination demonstrated that only mild foreign body reactions occurred at the embolisation site. Overall tolerance was good. The micropellets were shown to possess some biodegradation properties and to be susceptible to deformation. An attempt is made to define the ideal micropellet from the point of view of size, kinetic features, and biodegradation properties.