Related Experiment Video
Updated: Aug 11, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Abstract:
If only 1 per cent of the 23 million hypertensive patients in the United States had renovascular hypertension, many patients would be denied the chance for cure. Strong clinical suspicion plus arteriography are the mainstays of diagnosis. Positive renal vein renin studies provide the best preoperative evidence for cure by operation, but many patients with negative studies benefit from operation. Surgeons have been ingenious in devising methods of renal revascularization. Those we prefer are listed in Table 12-6. In most cases it should be possible to revascularize the kidney successfully without resorting to nephrectomy. About nine out of ten patients should benefit from operation; of these, some should be cured and others improved even though antihypertensive medication might be required.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Hypertension II: Pathophysiology

