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Related Experiment Videos

Selective plasma component removal: alternatives to plasma exchange

A A Pineda, H F Taswell

    Artificial Organs
    |August 1, 1981
    PubMed
    Summary

    Selective plasma component removal offers a cost-effective and efficient alternative to plasma exchange. These advanced techniques utilize physical or chemical methods for targeted component removal, improving therapeutic outcomes.

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    Area of Science:

    • Biomedical Engineering
    • Clinical Chemistry

    Background:

    • Plasma exchange (PEX) is a therapeutic apheresis technique with broad applications but significant cost barriers.
    • High costs are primarily due to the need for homologous replacement solutions.
    • The search for more economical and physiologically compatible alternatives to PEX is ongoing.

    Purpose of the Study:

    • To review state-of-the-art alternatives to conventional plasma exchange.
    • To highlight techniques for selective removal of plasma components.
    • To compare the potential and limitations of these alternative methods.

    Main Methods:

    • Review of physical and chemical methods for selective plasma component removal.
    • Discussion of on-line and off-line systems, including hemoperfusion and plasmaperfusion.
    • Analysis of membrane filtration, cryoprecipitation, and chemical precipitation techniques.

    Main Results:

    • Selective removal allows the use of autologous plasma as replacement fluid, reducing costs and improving physiological compatibility.
    • Various techniques like hemoperfusion, plasmaperfusion, membrane filtration, and precipitation enable targeted component depletion.
    • These methods offer potential advantages in efficiency and cost-effectiveness over traditional PEX.

    Conclusions:

    • Selective plasma component removal represents a promising and viable alternative to plasma exchange.
    • The reviewed techniques provide tailored therapeutic apheresis options with reduced economic and physiological burdens.
    • Further evaluation of the potential and limitations of these advanced apheresis modalities is warranted.

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