Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neutrophil function in chronic liver disease

A C Campbell, M W Dronfield, P J Toghill

    Clinical and Experimental Immunology
    |July 1, 1981
    PubMed
    Summary

    Chronic liver disease impairs neutrophil function due to plasma defects, not intrinsic neutrophil abnormalities. These defects in neutrophil locomotion and phagocytosis vary by liver disease etiology, impacting immune response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rostrate pedicellariae: A morphologically distinct form of echinoid test appendage.

    Journal of morphology·2018
    Same author

    Metal-on-metal surface hip arthroplasty in patients with abnormal Coxanatomy: preliminary results.

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2017
    Same author

    An unfavourable outcome after periprosthetic fracture following metal-on-metal surface hip arthroplasty.

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2017
    Same author

    Attitudes of farm consultants in the South Island of New Zealand towards the role of veterinarians in farm businesses.

    New Zealand veterinary journal·2016
    Same author

    An active video game intervention does not improve physical activity and sedentary time of children at-risk for developmental coordination disorder: a crossover randomized trial.

    Child: care, health and development·2015
    Same author

    Avulsion fracture of the coracoid process.

    Emergency medicine journal : EMJ·2010

    Area of Science:

    • Immunology
    • Hepatology
    • Cell Biology

    Background:

    • Chronic liver disease (CLD) can affect immune cell function.
    • Neutrophils play a critical role in host defense against pathogens.
    • Impaired neutrophil function may contribute to increased infection risk in CLD patients.

    Purpose of the Study:

    • To investigate neutrophil locomotion, phagocytosis, and killing activity in patients with various types of CLD.
    • To determine if observed functional impairments stem from intrinsic neutrophil defects or plasma abnormalities.
    • To explore potential correlations between plasma defects and specific CLD etiologies.

    Main Methods:

    • Studied neutrophil functions (locomotion, phagocytosis, killing) in 44 CLD outpatients (ALD, CAH, PBC, CC) and controls.
    • Assessed neutrophil function using autologous plasma and plasma from healthy donors.
    • Measured opsonization of Candida albicans and brewer's yeast.
    • Analyzed plasma levels of C3, C4, immune complexes, and IgA.

    Main Results:

    • Neutrophil locomotion was significantly depressed in alcoholic liver disease (ALD) and cryptogenic cirrhosis (CC) when using autologous plasma.
    • Patients' neutrophils exhibited normal locomotion with healthy donor plasma, indicating plasma-derived defects.
    • Plasma from chronic active hepatitis (CAH) patients showed reduced phagocytosis, but neutrophils functioned normally with normal plasma.
    • No intrinsic neutrophil abnormalities were detected across the CLD groups.

    Conclusions:

    • Impaired neutrophil locomotion and phagocytosis in CLD are primarily caused by plasma defects, not intrinsic neutrophil dysfunction.
    • The nature of these plasma defects differs based on the underlying etiology of cirrhosis.
    • These findings highlight the complex interplay between liver disease and immune cell function, impacting host defense mechanisms.

    Related Experiment Videos