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Effect of calcium infusion on post-reactive hypoglycemia
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|November 1, 1981
Summary
Continuous calcium infusion effectively suppressed reactive hypoglycemia in patients by increasing plasma glucose levels. Normal subjects showed no significant changes in glucose tolerance or insulin secretion.
Area of Science:
- Endocrinology
- Metabolic Disorders
Background:
- Reactive hypoglycemia is characterized by low plasma glucose levels after meals.
- The role of calcium in glucose metabolism and its potential therapeutic effects are not fully understood.
Purpose of the Study:
- To investigate the effect of continuous calcium infusion on reactive hypoglycemia.
- To assess calcium's impact on glucose tolerance and insulin secretion in both normal subjects and patients with reactive hypoglycemia.
Main Methods:
- A randomized, controlled study involving 9 healthy individuals and 14 patients with reactive hypoglycemia.
- Two five-hour oral glucose tolerance tests (OGTT) were performed, with participants receiving either normal saline or calcium infusion.
- Plasma glucose and calcium levels were monitored throughout the tests.
Main Results:
- Calcium infusion significantly increased plasma calcium levels in all participants.
- In patients with reactive hypoglycemia, calcium infusion led to a significant increase in plasma glucose and a disappearance of hypoglycemic symptoms.
- Normal subjects did not experience significant changes in glucose tolerance or insulin secretion.
Conclusions:
- Continuous calcium infusion effectively suppresses reactive hypoglycemia.
- Calcium may play a crucial role in managing reactive hypoglycemia by modulating glucose levels.