Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Accelerated lesion development in experimental syphilis

T J Fitzgerald

    Infection and Immunity
    |November 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Syphilis lesion development can be accelerated by multiple Treponema pallidum inoculations. This study observed shortened incubation periods when rabbits received combined doses, contrary to typical delayed responses with lower concentrations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Editorial: Importance of quality assurance in radiation oncology clinical trials.

    Frontiers in oncology·2026
    Same author

    Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas.

    International journal of radiation oncology, biology, physics·2024
    Same author

    Erectile Dysfunction and End-Stage Kidney Disease.

    Irish medical journal·2023
    Same author

    Editorial: Rising stars in radiation oncology 2022.

    Frontiers in oncology·2023
    Same author

    Report of the Medical Image De-Identification (MIDI) Task Group -- Best Practices and Recommendations.

    ArXiv·2023
    Same author

    Local Control For High-Grade Nonrhabdomyosarcoma Soft Tissue Sarcoma Assigned to Radiation Therapy on ARST0332: A Report From the Childrens Oncology Group.

    International journal of radiation oncology, biology, physics·2021
    Same journal

    The cholesterol-dependent cytolysin promotes <i>Streptococcus</i> systemic spread and induces arachidonic acid accumulation-mediated lethality in a murine intraperitoneal infection model.

    Infection and immunity·2026
    Same journal

    Phenotypic and genotypic analysis of <i>Candida albicans</i> vaginal isolates reveals that <i>ECE1</i> expression underpins pathogenicity.

    Infection and immunity·2026
    Same journal

    <i>Staphylococcus aureus</i> pore-forming toxins differentially shape disease severity in experimental endophthalmitis.

    Infection and immunity·2026
    Same journal

    Group B streptococcal membrane vesicles induce proinflammatory responses in neonatal meninges.

    Infection and immunity·2026
    Same journal

    <i>Pseudomonas aeruginosa</i> infection causes lysosomal dysfunction in the cystic fibrosis bronchial epithelium.

    Infection and immunity·2026
    Same journal

    The role of probiotics in restoring and maintaining vaginal microbiome health: a review.

    Infection and immunity·2026
    See all related articles

    Area of Science:

    • Microbiology
    • Immunology
    • Pathology

    Background:

    • Experimental syphilis lesion development is dose-dependent.
    • Lower concentrations of Treponema pallidum typically result in delayed incubation periods and less severe pathology.

    Purpose of the Study:

    • To investigate the effect of multiple, varied inocula of Treponema pallidum on lesion development and incubation periods in a rabbit model.
    • To characterize an unusual acceleration of incubation period observed with specific inoculation protocols.

    Main Methods:

    • Intradermal inoculation of rabbits with varying concentrations of Treponema pallidum (10^6, 10^5, 10^4, 10^3 treponemes).
    • Comparison of incubation periods between single-dose inoculations and simultaneous multi-dose inoculations on the same animal.
    • Histopathological analysis of syphilitic lesions.

    Related Experiment Videos

    Main Results:

    • Single inoculations resulted in incubation periods of 4.2, 7.5, 11.0, and 15.3 days for 10^6, 10^5, 10^4, and 10^3 treponemes, respectively.
    • Simultaneous inoculation with all four doses significantly shortened incubation periods to 3.9, 6.0, 7.0, and 8.9 days.
    • More pronounced acceleration was observed with wider ranges of treponemal inocula.

    Conclusions:

    • Multiple, varied inocula of Treponema pallidum can accelerate lesion development in experimental syphilis.
    • This finding challenges the conventional understanding of dose-dependent incubation periods in syphilis.
    • Further investigation into the histopathology of these accelerated lesions is warranted.