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Group G streptococcal colonization and sepsis in neonates
The Journal of Pediatrics
|December 1, 1981
Summary
Group G streptococci infections in newborns are rare but serious. While most infants responded to antibiotics, colonization by Group G streptococci may prevent Group B streptococci colonization.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Group G streptococci (GGS) are increasingly recognized as a cause of neonatal infections.
- Neonatal sepsis remains a significant cause of morbidity and mortality in newborns.
Purpose of the Study:
- To investigate the clinical presentation and outcomes of neonatal sepsis caused by GGS.
- To assess the prevalence of GGS and Group B streptococci (GBS) colonization in neonates.
Main Methods:
- Retrospective case series of seven neonates with GGS bloodstream infections.
- One-year prospective survey of GGS and GBS colonization at discharge (Day 3).
Main Results:
- Seven neonates developed GGS sepsis; most were preterm and presented with sepsis symptoms.
- One case had severe complication (epidermolysis bullosa) and died; six responded to antibiotics.
- Monthly GGS colonization ranged from 41-76%, while GBS colonization was 1-11%.
- Statistical analysis indicated a potential mutual exclusivity between GGS and GBS colonization.
Conclusions:
- GGS can cause severe neonatal sepsis, though outcomes are often favorable with prompt antibiotic treatment.
- The findings suggest a possible inverse relationship between GGS and GBS colonization in neonates.
- Further research is warranted to understand the implications of GGS colonization and its interaction with GBS.