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Related Experiment Videos

Adrenergic responsiveness in prehypertensive subjects

T A Kotchen, G P Guthrie, H McKean

    Circulation
    |February 1, 1982
    PubMed
    Summary

    Young men with higher blood pressure showed reduced sensitivity to alpha and beta agonists, suggesting adrenergic alterations may precede hypertension. Baroreflex sensitivity remained unchanged in these individuals.

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    Area of Science:

    • Cardiovascular Physiology
    • Hypertension Research
    • Adrenergic Signaling

    Background:

    • Elevated blood pressure in youth can predict future hypertension.
    • Adrenergic system activity is implicated in blood pressure regulation.
    • Understanding early adrenergic changes is crucial for predicting hypertension.

    Purpose of the Study:

    • To investigate if adrenergic activity alterations precede the development of hypertension in young men.
    • To assess the pressor response to an alpha-agonist and chronotropic response to a beta-agonist in prehypertensive individuals.
    • To examine baroreflex sensitivity and plasma renin activity in relation to blood pressure levels.

    Main Methods:

    • Recruited young men from high school populations based on blood pressure deciles (high vs. low).

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  • Administered phenylephrine (alpha agonist) and isoproterenol (beta agonist) to assess pressor and chronotropic effects.
  • Measured baroreflex slopes, plasma renin activity after exercise, and plasma norepinephrine levels.

    • Main Results:

    • Individuals with higher blood pressure required higher doses of phenylephrine (PD20) and isoproterenol (CD25) for desired effects.
    • Baroreflex sensitivity did not differ between high and low blood pressure groups.
    • Increased systolic blood pressure correlated with reduced sensitivity to both agonists and higher plasma norepinephrine.
    • Elevated plasma renin activity response to exercise was lower in the high blood pressure group.

    Conclusions:

    • Baroreflex sensitivity is not altered in young men with relatively high blood pressure.
    • Insensitivity to alpha and beta agonists may be linked to elevated systolic blood pressure and plasma norepinephrine.
    • Adrenergic system alterations, specifically reduced agonist sensitivity, may precede the onset of hypertension.