[Analysis of controlled studies comparing mianserin and clomipramine (author's transl)]

The analysis of three controlled studies comparing mianserin and clomipramine shows that none of them has elicited statistically significant differences between drugs, although populations were different: primary depression almost equally divided in endogenous and exogenous cases (de Buck), primary depression mostly neurotic (Pinder), involutional melancholia (Blaha). The only difference found as to efficacy was a more precocious onset of action for mianserin in the group of the endogenous depressions (de Buck). Mianserin causes significantly less side effects, above all as to hypotension, dry mouth, tremor and blurred vision.