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Pulsatile cardiopulmonary bypass. A review

K M Taylor

    The Journal of Cardiovascular Surgery
    |November 1, 1981
    PubMed
    Summary

    Pulsatile perfusion during cardiopulmonary bypass offers hemodynamic and metabolic advantages. Current pulsatile pump systems are safe and reliable for routine open-heart surgery.

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    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering

    Background:

    • Cardiopulmonary bypass (CPB) is a critical procedure in open-heart surgery.
    • Traditional CPB utilizes non-pulsatile (continuous) flow, which may have suboptimal physiological effects.
    • Pulsatile perfusion, mimicking the natural heartbeat, has emerged as a potential improvement.

    Purpose of the Study:

    • To review the experimental evidence supporting the superiority of pulsatile perfusion.
    • To discuss the hemodynamic and metabolic benefits of pulsatile flow.
    • To assess the practical aspects and clinical suitability of current pulsatile pump systems.

    Main Methods:

    • Review of experimental studies on pulsatile perfusion.
    • Analysis of hemodynamic and metabolic data comparing pulsatile and non-pulsatile flow.
    • Evaluation of pulsatile pump system mechanisms and waveform generation.
    • Discussion of hemolysis studies related to pulsatile perfusion.

    Main Results:

    • Pulsatile perfusion demonstrates significant hemodynamic and metabolic advantages over non-pulsatile flow.
    • Available pulsatile pump systems generate specific arterial waveforms.
    • Studies on hemolysis indicate acceptable levels during pulsatile perfusion.
    • Current systems are suitable for clinical integration.

    Conclusions:

    • Pulsatile perfusion offers demonstrable benefits in open-heart surgery.
    • Existing pulsatile pump systems are reliable and safe for routine clinical use.
    • The integration of pulsatile perfusion enhances the safety and efficacy of CPB.

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