Graft reactions after unilateral and bilateral keratoplasty for keratoconus

Penetrating keratoplasty was performed on 134 eyes with keratoconus (102 patients) Including 32 bilateral cases. The incidence of homograft rejection in the first eye of bilateral cases before surgery was performed on the second eve was identical to the incidence in unilateral cases (16%). The incidence of graft rejection was somewhat higher (25%) in the second eye of bilateral surgery, but this difference in rates of rejection was not statistically significant. Surgery on the second eye affected adversely the successful graft on the first even in only one case and this was resolved with medical therapy.