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A multicentre open trial indapamide in general practice

C H Bowker, M A Murphy

    Postgraduate Medical Journal
    |January 1, 1981
    PubMed
    Summary
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    Indapamide effectively lowers blood pressure in hypertensive patients, showing significant reductions in systolic and diastolic pressure within four months. Long-term treatment maintained blood pressure control with no severe side effects reported.

    Area of Science:

    • Cardiology
    • Pharmacology
    • General Practice

    Background:

    • Hypertension is a prevalent global health issue requiring effective and safe therapeutic options.
    • Diuretics, such as indapamide, are a cornerstone in managing elevated blood pressure.
    • Optimizing antihypertensive therapy in diverse patient populations remains a clinical challenge.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of indapamide (2.5 mg daily) in a general practice setting.
    • To assess blood pressure reduction in patients with and without prior antihypertensive treatment.
    • To determine the long-term effectiveness and safety profile of indapamide.

    Main Methods:

    • A multicentre open-label study involving 99 patients treated with indapamide 2.5 mg daily.

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  • Patients were categorized based on prior antihypertensive therapy status.
  • Blood pressure measurements were recorded at baseline and after 4 months of treatment; a subset was followed for 12 months.

    • Main Results:

    • A mean reduction of 26 mmHg systolic and 17 mmHg diastolic blood pressure was observed in 85 completers after 4 months.
    • Blood pressure control was sustained in the majority of patients followed for at least 12 months.
    • No severe adverse events were reported during the study period.

    Conclusions:

    • Indapamide (2.5 mg daily) demonstrates significant efficacy in reducing blood pressure in a general practice setting.
    • The drug is well-tolerated, with sustained effectiveness for long-term hypertension management.
    • Indapamide represents a valuable therapeutic option for initiating or augmenting antihypertensive treatment.