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Echocardiographic evaluation of left ventricular function in patients showing an antihypertensive and biochemical
Insights
Indapamide effectively lowers blood pressure in hypertensive patients without negatively impacting left ventricular function. While it caused minor electrolyte shifts, these remained within normal limits, indicating a favorable safety profile.
Area of Science:
- Cardiology
- Pharmacology
- Hypertension Management
Background:
- Hypertension is a major risk factor for cardiovascular disease.
- Left ventricular function is a key indicator of cardiac health.
- Assessing the impact of antihypertensive medications on cardiac function is crucial.
Purpose of the Study:
- To evaluate the effect of indapamide on left ventricular function in hypertensive patients.
- To assess the blood pressure-lowering efficacy of indapamide.
- To monitor biochemical parameters and identify potential side effects.
Main Methods:
- Non-invasive echocardiography was used to measure velocity of circumferential fibre shortening (VCF).
- Blood pressure was measured in standing, supine, and post-exercise positions.
- Serum electrolytes, uric acid, and blood lipids were analyzed pre- and post-treatment.
Main Results:
- Indapamide significantly reduced systolic and diastolic blood pressure (P < 0.001).
- No significant alterations in left ventricular function (VCF) were observed.
- Minor, clinically insignificant changes in serum potassium and uric acid were noted; serum sodium and chloride remained within normal ranges.
Conclusions:
- Indapamide is effective in reducing blood pressure in hypertensive patients.
- Indapamide does not adversely affect left ventricular function.
- Indapamide demonstrates a favorable safety profile with manageable biochemical changes.
Abstract:
Left ventricular function was evaluated non-invasively in hypertensive patients treated with indapamide by means of echographically determined velocity of circumferential fibre shortening (VCF). A statistically significant reduction in mean systolic and diastolic blood pressure in both the standing and supine position (P less than 0.001) and after exercise, systolic (P less than 0.001) diastolic (P less than 0.05) occurred but no alteration in left ventricular function was found. Blood lipids showed no change from pre-treatment levels. Serum uric acid demonstrated a significant elevation and serum potassium a significant fall but each remained within the normal range. Three patients required potassium supplementation. A significant rise in serum sodium and fall in serum chloride, both remaining within the normal range, occurred.