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Related Concept Videos

Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

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The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Updated: Sep 30, 2025

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates
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Epithelial cell-cell and cell substrate contacts

J Overton, R Meyer, E A Chernoff

    Scanning Electron Microscopy
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Maintaining epithelial tissue requires balancing cell-cell and cell-substrate contacts during proliferation. Studies explore this by manipulating tissue components and observing developmental changes in cell adhesion and growth.

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    Electric Cell-substrate Impedance Sensing for the Quantification of Endothelial Proliferation, Barrier Function, and Motility
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    Area of Science:

    • Cell biology
    • Developmental biology
    • Tissue engineering

    Background:

    • Epithelial tissue morphology relies on a balance of cell-cell and cell-substrate adhesion.
    • This balance must adapt to cellular proliferation during tissue development and maintenance.

    Purpose of the Study:

    • To analyze the factors influencing epithelial tissue morphology and cell adhesion.
    • To investigate inherent differences in cell behavior when separated from their native tissue environment.
    • To understand the relationship between cell-cell interactions and tissue proliferation rates.

    Main Methods:

    • Recombination of cellular and matrix tissue components.
    • Analysis of developmental changes in intact epithelial tissues.
    • Culturing epithelial and mesenchymal cells on denuded tissue matrices.
    • Observing cell expansion on different surfaces of the vitelline membrane.
    • Studying cell aggregation and desmosome formation in dispersed cells.
    • Correlating junctional domain size with proliferative rates in developing chick liver.

    Main Results:

    • Epithelial and mesenchymal cells exhibit distinct behaviors on denuded matrices, indicating inherent differences.
    • Chick epiblast expansion mode alters when grown on the outer versus inner vitelline membrane surface.
    • Individual cells can influence desmosome formation in aggregating cells.
    • A correlation exists between the percentage of lateral cell surface in the junctional domain and cell proliferation rate in developing chick liver.

    Conclusions:

    • Cellular interactions and substrate adhesion are critical for maintaining epithelial morphology.
    • Tissue recombination and developmental studies provide insights into cell behavior and differentiation.
    • Cell-cell communication plays a role in adhesion structure formation.
    • Cell proliferation is linked to the extent of cell-cell junctional domains.