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Updated: Aug 17, 2026

T-wave Ion Mobility-mass Spectrometry: Basic Experimental Procedures for Protein Complex Analysis
Published on: July 31, 2010
Structure of the fibers of hemoglobin S
Abstract:
Several lines of evidence are converging on a consistent model for the structure of the fibers of hemoglobin S. The basic structure of the fibers is a solid helical assembly of 14 protofilaments deduced from three-dimensional reconstructions of electron micrographs. The filaments are organized in half-staggered pairs which appear to be related to the pairs of filaments in a crystal form of hemoglobin S studied by X-ray diffraction. This relationship between fibers and crystals suggests an orientation of the hemoglobin S molecules in the fibers and the regions of the molecules that contribute to the various intermolecular contacts.
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