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Steroid diabetes in childhood
American Journal of Diseases of Children (1960)
|January 1, 1982
Summary
Corticosteroid therapy in children can lead to hyperglycemia and glycosuria. Early detection through blood glucose monitoring is faster than symptom-based diagnosis, enabling timely management of steroid-induced diabetes.
Area of Science:
- Pediatric Endocrinology
- Pharmacology
Background:
- Corticosteroids are widely used in pediatric treatment for various conditions.
- Hyperglycemia and glycosuria are recognized potential side effects of corticosteroid use in children.
Purpose of the Study:
- To analyze episodes of hyperglycemia and glycosuria in pediatric patients receiving corticosteroids.
- To compare detection times and outcomes of steroid-induced hyperglycemia.
Main Methods:
- Retrospective analysis of 24 episodes in 17 pediatric patients treated with corticosteroids between 1968 and 1979.
- Evaluation of detection methods (symptom-based vs. biochemical monitoring) and associated complications.
Main Results:
- Detection via symptoms averaged 26 days, while biochemical monitoring averaged 4.5 days.
- Severe hyperglycemia (glucose > 500 mg/dL) occurred in 8 patients; 4 experienced ketosis, and 2 had acidosis.
- Insulin therapy was required in 15 episodes, with 4 patients developing permanent insulin dependence.
Conclusions:
- Steroid-precipitated diabetes in children requires anticipation and monitoring.
- Prompt detection through glucose monitoring is crucial for managing hyperglycemia.
- Management of the primary disease should not be hindered by the risk of steroid-induced diabetes.