[Reactive changes in autonomic synapses during frequency electric stimulation]

Reactive modifications of synapses of isolated intratrunkal vegetative neurones induced by high frequency orthodromal electric stimulation have been examined by vital phase-contrast microscopy, electron microscopy, vital staining with methylene blue in conjunction with concurrent electrophysiological control Flocculent aggregation of the synaptoplasma and vesicles has been discovered, which is associated with higher adhesiveness of modified proteins. There have been also discovered matrix translucence and rounding of the living synaptic buds, which is accounted for by segregation of the hydration fraction of the neuroplasma. The decrease in the number of light synaptic vesicles is accompanied by the appearance of osmiophilic, myelin-like bodies, dense-core vesicles and glycogen-like granules. An attempt has been made to validate the process in terms of the colloid-chemical conception.