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Related Experiment Videos

Specific estrogen receptors in human gingiva

J Vittek, M R Hernandez, E J Wenk

    The Journal of Clinical Endocrinology and Metabolism
    |March 1, 1982
    PubMed
    Summary

    Human gingiva contains estrogen receptors that bind 17 beta-estradiol. These receptors are present in various gingival cells, suggesting the gingiva may act as a target organ for estrogen.

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    Area of Science:

    • Endocrinology
    • Oral Biology
    • Histology

    Background:

    • Estrogen receptors are crucial in various physiological processes.
    • The role of estrogen in oral tissues, specifically the gingiva, remains largely unexplored.

    Purpose of the Study:

    • To investigate the presence and characteristics of estrogen receptors in human gingiva.
    • To determine if human gingiva can function as a target organ for estrogens.

    Main Methods:

    • Cytoplasmic receptor binding assays using 17 beta-estradiol and moxestrol.
    • Heat and protease sensitivity tests for receptor characterization.
    • Autoradiographic techniques to assess nuclear uptake of [3H]estradiol in gingival tissues.
    • Comparison of receptor characteristics in normal, diseased, and Dilantin-hyperplastic gingiva.

    Main Results:

    • Human gingival cytoplasm contains high-affinity, low-capacity estrogen receptors.
    • Receptor binding is sensitive to heat and proteolytic enzymes, similar to known estrogen receptors.
    • Specific nuclear localization of estrogen was observed in gingival epithelial, stromal, and vascular cells.
    • No significant differences in receptor affinity or number were found based on age, sex, or disease state, except for Dilantin hyperplasia.

    Conclusions:

    • Human gingiva possesses specific estrogen-binding receptors.
    • Estrogen can be taken up into the nucleus of various gingival cells.
    • These findings provide the first direct evidence that human gingiva may function as a target organ for estrogens.

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