Implantation of an intracerebral cannula in the mouse

A technique for implanting a permanent stainless steel cannula into the lateral ventricles of mice is described. The model is of particular interest because it permits study of the behavioral effects of acute or repeated administrations of substances in the brains of conscious mice. The method can be used for injection into parenchymal structures. A study of dexamphetamine effects on body temperature is presented to demonstrate the use of this technique.