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Related Experiment Videos

Renal vasoactive hormones in scleroderma (progressive systemic sclerosis)

J A Oliver, J M Vinci, R E Bowden

    Nephron
    |January 1, 1981
    PubMed
    Summary

    This study found that the renal kallikrein-kinin and prostaglandin systems are normal in patients with progressive systemic sclerosis (PSS) who do not have apparent kidney disease, suggesting these systems are not altered in early-stage PSS.

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    Area of Science:

    • Nephrology
    • Rheumatology
    • Endocrinology

    Background:

    • Progressive systemic sclerosis (PSS) can affect renal function.
    • Understanding the role of renal systems in PSS is crucial for early detection and management.
    • The kallikrein-kinin and prostaglandin systems are key regulators of renal hemodynamics and sodium balance.

    Purpose of the Study:

    • To investigate plasma renin activity and urinary kallikrein, kinin, immunoreactive PGE (iPGE), and aldosterone excretion in PSS patients without clinically apparent renal disease.
    • To compare these parameters with sex- and race-matched normal controls.
    • To determine if the renal kallikrein-kinin and prostaglandin systems are altered in early PSS.

    Main Methods:

    • Assessed plasma renin activity (PRA) and urinary excretions of kallikrein, kinin, iPGE, and aldosterone.

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  • Maintained a fixed sodium and potassium intake for all participants.
  • Included 23 patients with PSS and a control group of healthy individuals.

    • Main Results:

    • Urinary kallikrein and kinin excretions were not significantly different between PSS patients and controls.
    • Urinary iPGE excretion was normal in female PSS patients.
    • Upright PRA was appropriate for urinary sodium excretion in most PSS patients, but elevated in a small subgroup of normotensive individuals.

    Conclusions:

    • The renal kallikrein-kinin system appears unaltered in PSS patients without clinical renal disease.
    • The renal prostaglandin system also seems unaffected in this patient cohort.
    • These findings suggest that early PSS may not involve significant dysregulation of these specific renal systems.