Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nerve allograft response: a quantitative immunological study

S Mackinnon, A Hudson, R Falk

    Neurosurgery
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Embedding patient and public involvement into a doctoral study: developing a point-of-care HIV testing intervention for dental settings.

    Frontiers in oral health·2024
    Same author

    Assessing domain match and feasibility of candidate instruments matching with OMERACT endorsed domains to measure flare in knee and hip osteoarthritis.

    Seminars in arthritis and rheumatism·2024
    Same author

    Acute and Chronic Demyelinating Polyneuropathy post AstraZeneca Covid-19 Vaccine.

    Irish medical journal·2023
    Same author

    General Order in Reference to Sanitary Precautions: General Order-No 5.

    The Chicago medical journal·2023
    Same author

    Methodical control of the difficult pediatric airway: two case reports.

    Journal of medical case reports·2023
    Same author

    Influence of sediment quality and microbial community on the functioning capacity of a constructed wetland treating alkaline leachate after 5.5 years in operation.

    The Science of the total environment·2023
    Same journal

    Performance of Risk Scores in Predicting Intracranial Aneurysm Instability.

    Neurosurgery·2026
    Same journal

    Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

    Neurosurgery·2026
    Same journal

    Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis.

    Neurosurgery·2026
    Same journal

    Safety and Efficacy of 3-Month Versus 6-Month Duration of Dual Antiplatelet Therapy in Pipeline Embolization Treatment of Intracranial Aneurysms.

    Neurosurgery·2026
    Same journal

    Risk Factors of Revision Surgery After Acute Proximal Junctional Fracture Following Adult Spinal Deformity Surgery.

    Neurosurgery·2026
    Same journal

    Sensorimotor Network Alterations and Compensation in Cervical Spondylotic Myelopathy: A 7 T Task-Based and Resting-State Functional MRI Study.

    Neurosurgery·2026
    See all related articles

    Nerve allograft rejection varies by rat strain relatedness. Closely related strains show delayed sensitization, unlike skin grafts, indicating unique nerve-specific immune responses.

    Area of Science:

    • Immunology
    • Transplantation Biology
    • Neuroscience

    Background:

    • Histocompatibility differences between rat strains influence immune responses.
    • Nerve allograft rejection mechanisms are not fully understood.
    • Rat strains Lewis (RTl1), Fischer (RTl1), Buffalo (RTlb), and ACI (RTla) exhibit varying degrees of genetic disparity.

    Purpose of the Study:

    • To investigate the nerve allograft response in rats with differing histocompatibility loci.
    • To compare nerve allograft sensitization timing with skin allograft responses.
    • To determine if nerve graft origin is discernible through histological examination.

    Main Methods:

    • Utilized Lewis rats as recipients for nerve allografts from Fischer, Buffalo, and ACI strains.
    • Employed the 51Cr release cytotoxicity assay to quantify antigen recognition and immune sensitization.

    Related Experiment Videos

  • Conducted histological assessments of nerve allografts to evaluate tissue changes.

    • Main Results:

    • Early sensitization (Day 8) observed with ACI and Buffalo nerve allografts, which differ at the major histocompatibility locus.
    • Delayed sensitization (Day 80) occurred in Lewis/Fischer pairings, differing only at minor histocompatibility loci.
    • Skin allografts showed rapid sensitization (Day 10) across all tested strain combinations.
    • Histological changes in nerve allografts were consistent across Fischer, Buffalo, and ACI donor strains.

    Conclusions:

    • Nerve allograft rejection timing is significantly influenced by the degree of donor-recipient genetic disparity.
    • Nerve allografts exhibit a distinct sensitization profile compared to skin allografts.
    • Histological examination alone cannot reliably identify the donor strain of a nerve allograft.