Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacteriophage-host interactions in assembly

C Georgopoulos, K Tilly

    Progress in Clinical and Biological Research
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Comparison of the genome for phylogenetically related bacteriophages phiKZ and EL of Pseudomonas aeruginosa: evolutionary aspects and minimal genome size].

    Genetika·2005
    Same author

    Genetics and regulation of chitobiose utilization in Borrelia burgdorferi.

    Journal of bacteriology·2001
    Same author

    The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth.

    Journal of bacteriology·2001
    Same author

    Identification of important amino acid residues that modulate binding of Escherichia coli GroEL to its various cochaperones.

    Genetics·2001
    Same author

    Telomere resolution in the Lyme disease spirochete.

    The EMBO journal·2001
    Same author

    Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.

    The Journal of biological chemistry·2001

    Bacteriophages rely on bacterial machinery for their life cycle. This study investigates bacterial mutants that disrupt phage assembly, revealing host roles in morphogenesis.

    Area of Science:

    • Microbiology
    • Molecular Biology
    • Virology

    Background:

    • Bacteriophages (phages) possess small genomes, necessitating reliance on host bacterial machinery for replication, transcription, translation, and morphogenesis.
    • Phage and host functions often operate in parallel, exemplified by T4 phage and host DNA ligase interactions.

    Purpose of the Study:

    • To elucidate the specific contributions of host bacterial functions to bacteriophage morphogenesis.
    • To genetically map host factors essential for successful phage assembly.

    Main Methods:

    • Isolation and characterization of bacterial mutants exhibiting defects in phage morphogenesis.
    • Preliminary genetic analysis to identify host genes involved in phage assembly.

    Main Results:

    Related Experiment Videos

    • Identification of bacterial mutants that specifically block phage morphogenesis.
    • Preliminary genetic data indicating the host's role in phage assembly processes.

    Conclusions:

    • Bacterial mutants blocking phage morphogenesis provide valuable genetic insights into host-phage interactions.
    • Future biochemical studies, including in vitro reconstitution, are planned to precisely define the roles of bacterial gene products in phage assembly.