The nature of prostaglandin-like substances released from guinea-pig lung in anaphylaxis

The pulmonary inactivation of infused prostaglandin E2 by isolated perfused lungs of guinea pigs was inhibited with di-4 phloretin phosphate (DPP) without significantly altering the antigen-induced release of prostaglandin-like substances or histamine. Similar data were obtained when the lungs were perfused in a reverse direction. These results suggest that parent prostaglandins are not major constituents of the prostaglandin-like substances released from guinea-pig lungs during anaphylaxis.