Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Disorders of proximal nephron function

M G Cogan

    The American Journal of Medicine
    |February 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    The proximal nephron reabsorbs most filtered solutes like amino acids and glucose via sodium co-transport. Disorders arise from altered luminal, cellular, or peritubular factors affecting this crucial kidney function.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Alpha 1-adrenergic control of chloride transport in the rat S1 proximal tubule.

    The American journal of physiology·1996
    Same author

    Flow dependence of chloride transport in rat S1 proximal tubules.

    The American journal of physiology·1995
    Same author

    Kidney function and age are both predictors of pharmacokinetics of metformin.

    Journal of clinical pharmacology·1995
    Same author

    Chloride transport in the rat S1 proximal tubule.

    The American journal of physiology·1995
    Same author

    Pulmonary edema associated with salt water near-drowning: new insights.

    The American review of respiratory disease·1992
    Same author

    Comparison of inhibitory potency by nonpeptide angiotensin II receptor antagonists PD123177 and DuP 753 on proximal nephron and renal transport.

    The Journal of pharmacology and experimental therapeutics·1991
    Same journal

    GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

    The American journal of medicine·2026
    Same journal

    Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

    The American journal of medicine·2026
    Same journal

    Cave Canem - Beware of the Dog.

    The American journal of medicine·2026
    Same journal

    Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

    The American journal of medicine·2026
    Same journal

    Mesenteric Panniculitis.

    The American journal of medicine·2026
    Same journal

    Hypercalcemia and hyperferritinemia in a patient with Graves' disease disease.

    The American journal of medicine·2026
    See all related articles

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Cellular Transport

    Background:

    • The proximal nephron is critical for reabsorbing 80-99% of filtered solutes, including amino acids, glucose, and bicarbonate.
    • Sodium co-transport mechanisms are vital for solute reabsorption, which saturates at high luminal concentrations.
    • Chloride reabsorption involves passive and active mechanisms sensitive to osmotic gradients.

    Purpose of the Study:

    • To elucidate the mechanisms of proximal nephron reabsorption.
    • To describe the factors influencing solute and water transport in the proximal tubule.
    • To categorize disorders affecting proximal nephron function.

    Main Methods:

    • Analysis of solute and water reabsorption processes in the proximal tubule.
    • Investigation of sodium co-transport systems.

    Related Experiment Videos

  • Examination of passive and active transport mechanisms for chloride.
  • Review of factors affecting proximal tubule reabsorption, including luminal, cellular, and peritubular influences.

    • Main Results:

    • Proximal tubule reabsorption is isosmotic and isonatric, reabsorbing 50-60% of filtered sodium and water.
    • Reabsorption rates for solutes like amino acids, glucose, and bicarbonate are concentration-dependent and subject to transport maximum.
    • Disorders manifest due to altered tubular flow, luminal composition (e.g., mannitol), exceeding transport capacity (e.g., glycosuria), or defects in active transport systems (e.g., Fanconi syndrome).

    Conclusions:

    • Proximal nephron function relies on specific sodium co-transport mechanisms and is influenced by luminal, cellular, and peritubular factors.
    • Disruptions in these mechanisms lead to various renal disorders, including aminoacidurias, glycosurias, renal tubular acidosis, and Fanconi syndrome.
    • Understanding these transport processes is key to diagnosing and managing proximal tubule dysfunction.