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Related Experiment Videos

Membrane alterations in lymphocyte proliferation

G B Segel

    The American Journal of Pediatric Hematology/Oncology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Foreign antigen recognition by human lymphocytes triggers adaptive and regulatory changes, including ion transport and calcium metabolism, essential for immune responses like proliferation. Calcium regulation is key to initiating these immunologic processes.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Biochemistry

    Background:

    • Antibody and cell-mediated immunity depend on B- and T-lymphocyte interactions with foreign antigens.
    • Lymphocyte activation involves membrane receptor binding, leading to proliferation and immune responses.

    Purpose of the Study:

    • To investigate the early cellular and molecular changes in human lymphocytes upon encountering antigens or lectins.
    • To elucidate the role of ion transport and calcium metabolism in initiating lymphocyte proliferation and immunologic responses.

    Main Methods:

    • Observation of human lymphocyte responses to antigens and plant lectins.
    • Analysis of changes in membrane permeability, nutrient transport, and cation flux (Na+, K+, Ca2+).

    Main Results:

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    • Antigen/lectin binding initiates changes in membrane permeability and nutrient/cation transport.
    • Increased sodium and potassium transport are adaptive, supporting mitogenesis.
    • Altered calcium metabolism is regulatory, closely linked to proliferation initiation.

    Conclusions:

    • Lymphocyte activation involves complex ion flux and calcium regulation.
    • Internal calcium concentration changes are critical for regulating lymphocyte secretion, contraction, and proliferation.
    • Calcium's role may involve direct enzyme interaction or calmodulin-mediated pathways.