Efficacy of ethylenediamine dihydrochloride in dogs and cats

Ethylenediamine dihydrochloride was administered to dogs and cats with induced Escherichia coli urinary tract infections and to clinically normal dogs and cats to determine if the drug had diuretic, antibacterial, or urinary acidification properties. In dogs, the drug had no diuretic or antibacterial properties and did not modify the postprandial production of alkaline urine. In cats, the drug had no diuretic or antibacterial properties, but caused a slight reduction in urine pH when multiple doses were administered. Ethylenediamine dihydrochloride appeared to have no value in the treatment of E coli urinary infection under the conditions of the present study.